Aminoglycoside Dosing: Synergy for Endocarditis
Calculate dosing weight (DW)
Estimate aminoglycoside clearance (AgCl):
GFR approximates aminoglycoside clearance, therefore MDRD clearance posted in Powerchart is a reasonable estimate of aminoglycoside clearance. Prior to utilizing MDRD, the result should be assessed to ensure that it is consistent with the patient’s clinical status (e.g. accuracy is suspect in patients not producing creatinine at a normal rate and MDRD results are not relevant for dialysis patients).
Estimate the aminoglycoside half-life:
Calculate dosing interval (DI)
Enterococcus spp. or Staphylococcus spp.
Aminoglycoside serum concentrations and renal function monitoring.
Duration of therapy